This endomembrane system template illustrates vesicular transport connecting organelles. Proteins synthesized in ER are packaged into COPII vesicles traveling to Golgi for sequential modifications across cisternae. The trans-Golgi network sorts proteins to secretory pathways, lysosomes via mannose-6-phosphate tags, or endocytic routes. Exocytosis releases content or inserts membrane proteins through SNARE-mediated fusion. Endocytosis internalizes materials through clathrin-coated pits, with early endosomes sorting cargo for recycling or lysosomal degradation. Essential for understanding diseases and drug development.
